Protein Details: Aquaporin-11

Protein ID

ICDB_Pro_1213

Protein Name

Aquaporin-11

Gene Name

Aqp11

Organism

Mus musculus (Mouse)

Length

271 amino acids

AlphaFoldDB

AF-Q8BHH1-F1-model_v4.pdb

Function

Channel protein that facilitates the transport of water; glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver; kidney and brain . In situation of stress; participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway . Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER . Plays a role in the proximal tubule function by regulating its endosomal acidification . May play a role in postnatal kidney development .

Sequence

MSALLGLRPEVQDTCISLGLMLLFVLFVGLARVIARQQLHRPVVHAFVLEFLATFQLCCCTHELQVLSEQDSAHPTWTLTLIYFFSLVHGLTLVGTASNPCGVMMQMILGGMSPEMGAVRLLAQLVSALCSRYCISALWSLSLTKYHYDERILACRNPIHTDMSKAIIIEAICSFIFHSALLHFQEVRTKLRIHLLAALITFLAYAGGSLTGALFNPALALSLHFPCFDELFYKFFVVYWLAPSVGVLMMILMFSFFLPWLHNNQMTNKKE

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Highly expressed in the S1 proximal tubule segment; (PubMed:23486012). Expressed in the testis; kidney; and liver. Weakly expressed in the heart; brain; and muscle. Weakly expressed in the heart; brain; and muscle. Weakly expressed in the heart; brain; and muscle. Highly expressed in the testis. Expressed in the proximal tubule of the cortex of 8-day-old mouse kidney (PubMed:16107722). Expressed in retina specifically at retinal Mueller glial cells (PubMed:27107718). Expressed in brain. Expressed abundantly at the choroid plexus but also expressed weakly in the parenchyma. Expressed at the capillary endothelium in the cerebral white matter (PubMed:27258268). Expressed in adult testis; in the elongated spermatids (ES) and in residual bodies inside Sertoli cells (PubMed:19812234).

DOI ID

10.1126/science.1112014; 10.1101/gr.2596504; 10.1128/mcb.25.17.7770-7779.2005; 10.1096/fj.08-111872; 10.1681/asn.2008030296; 10.1016/j.cell.2010.12.001; 10.1530/rep-09-0298; 10.1074/jbc.m110.180968; 10.1016/j.jsb.2011.01.003; 10.1152/ajpgi.00208.2012; 10.1152/ajprenal.00344.2012; 10.1681/asn.2013060614; 10.3390/ijms17060861; 10.1186/s12974-016-0554-2; 10.1152/ajprenal.00065.2016; 10.1016/j.bbrep.2019.01.003

RefSeq

NP_780314.1